Understanding Sulfhemoglobinemia: The Rare Condition of Green Blood Keywords: Sulfhemoglobinemia, green blood, sulfhemoglobin, hemoglobinopathy, hypoxia, cyanosis, sulfonamide drugs, dyshemoglobinemia, co-oximetry, hemoglobin modification Abstract Sulfhemoglobinemia is a rare hematological disorder in which sulfur atoms irreversibly bind to the heme moiety of hemoglobin, forming Sulfhemoglobin (SulfHb) that gives the blood a greenish or dark-green hue and significantly impairs oxygen transport (Docherty et al., 2020; Lu et al., 1998). This article reviews its biochemical mechanism, etiology, clinical manifestations, diagnostic challenges, case studies, treatment strategies, and prognosis, integrating environmental, pharmacological, and biochemical perspectives on this unusual hemoglobinopathy. Introduction Sulfhemoglobinemia represents a striking intersection of clinical medicine, toxicology, and biochemistry. Although exceedingly rare, it highlights how external agents—p...
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